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| Antigenic Specificity | Junctional Adhesion Molecule 3 (JAM3) |
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| Clone | CRAM-19 H36 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | 100 µg |
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| Concentration | n/a |
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| Applications | Immunoprecipitation (IP),Immunoassay (IA),Immunohistochemistry (Frozen Sections) (IHC (fro)),Flow Cytometry (FACS) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Junctional adhesion molecule-C (JAM-C) also known as JAM-2 is a 45 kD cell adhesion molecule (CAM). JAM-C is a transmembrane protein which is a member of the immunoglobulin superfamily found at intercellular junctions of endothelial cells. JAM-C belongs together with JAM-A (JAM or JAM-1) and JAM-B (VE-JAM or JAM-3) to a family of adhesion proteins with a V-C2 immunoglobulin domain organization. JAM plays an important role in tight junctions where it is involved in cell-to-cell adhesion through homophilic interaction. It codistributes with other tight junction components as ZO-1, 7H6 antigen, cingulin and occludin. JAM-C is potentially involved in the junctional sealing of the vascular endothelium, in particular of high endothelial venules (HEV). In adult murine tissue JAM-C expression is reported to be restricted to high endothelial venules of lymphoid organs, lymphoendothelial cells and endothelial cells in kidney. Monoclonal antibody CRAM-19 H36 also reacts with human JAM-C. In humans, JAM-C expression is not restricted to endothelial cells, but is also expressed on human lymphocytes. |
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| Immunogen | n/a |
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| Other Names | JAM3|jam3|sr:nyz155|wu:fb30h11|wu:fc08c06|wu:fc13e04|wu:fc25g11|jamc.2|1110002N23Rik|JAM-3|JAM-C|Jcam3|JAM-2|JAMC |
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| Gene, Accession # | Gene ID: 83964 |
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| Catalog # | ABIN2191806 |
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| Order / More Info | Junctional Adhesion Molecule 3 (JAM3) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 11053409, 12239159 |
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