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| Product Name | IL21, Recombinant, Human (IL-21, Za11, Interleukin-21) |
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| Description | Purity ~95% (SDS-PAGE). IL-21 stimulates proliferation of B cell stimulated by crosslinking of the CD40 antigen. It inhibits proliferation stimulated by IL-4 plus anti-IgM. IL-21 augments stimulation of the proliferation of naive CD45RA(+) but not memory CD45R0(+) T cells mediated by engagement of CD3. IL-21 stimulates the proliferation of bone marrow progenitor cells and the expression of the natural killer cell marker CD56 in the presence of IL-15. The Interleukin-21 receptor is closely related to human IL-2 beta receptor. The receptor contains a WSXWS motif in the extracellular region, typical of type 1 cytokine receptors. The receptor is expressed on natural killer cells, T cells, and B cell line. The functional signaling complex activates Janus kinases JAK1, JAK3, and the STAT proteins STAT1, and STAT3. Source: Recombinant protein corresponding to human IL21 expressed in E. coli. Molecular Weight: ~15kD Biological Activity: The ED50 was determined by the dose-dependent proliferation of HuT-78 Cells and w |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q9HBE4 |
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| Catalog # | 500136 |
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| Order / More Info | IL21, Recombinant, Human (IL-21, Za11, Interleukin-21) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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