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| Product Name | IL-33, Recombinant, Human (Interleukin-33, IL-1F11, NF-HEV) |
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| Description | Purity >90% (SDS-PAGE). Interleukin-33 (IL-33; HF-NEV; IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kD human IL33 is converted by CASP1 to a 18kD protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38 (MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis. Biological Activity: Activates human ST2-dependent NF-kappaB pathway. Sequence: Human IL-33 (aa 112-270) is fused at the C-terminus to a FLAG®-tag. |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Interleukin-33, IL-1F11, NF-HEV |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 44930 |
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| Order / More Info | IL-33, Recombinant, Human (Interleukin-33, IL-1F11, NF-HEV) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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