| 产品详情 |
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| Product Name | VEGFR/Tie-2/PDGFR Tyrosine Kinase Inhibitor |
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| Description | Purity ~95% (HPLC). An orally bioavailable pyrrolopyrimidinylurea compound that simultaneously binds to both the adenine and the adjacent hydrophobic pocket of the inactive form of VEGFR2 with high-affinity (type-II inhibitor) and acts as a pseudo-irreversible inhibitor with prolonged action. Shown to potently inhibit the activities of VEGFR2, VEGFR1, Tie-2, PDGFRa, PDGFRb and c-kit (IC50=6.2, 15, 20, 35, 96 and 170nM, respectively) with moderate to excellent selectivity over B-raf and Aurora-A (IC50=0.9 and 1.05uM) and FGFR1, HER2, EGFR, IR, PKCth (>10uM) among 18-kinases. Arrests VEGF-induced HUVECs proliferation (IC50=4.4uM) and suppresses DU145 carcinoma growth in a xenograft nude mouse model (6mg/kg, b.i.d.). Formula: C21H15F4N5O2 Molecular Weight: 445.4 Solubility: DMSO (100mg/ml) |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | VEGFR/Tie-2/PDGFR Tyrosine Kinase Inhibitor (1-(2-Fluoro-4-((5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy)phenyl)-3-(3-(trifluoromethyl)phenyl)urea, VEGFR Tyrosine Kinase Inhibitor XXXIV, VEGFR2 Kinase Inhibitor XXXII, VEGFR1 Kinase Inhibitor VII, PDGFR Tyrosine Kinase Inhibitor XXI) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217867 |
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| Order / More Info | VEGFR/Tie-2/PDGFR Tyrosine Kinase Inhibitor from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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