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| Product Name | VEGFR Tyrosine Kinase Inhibitor VI, AAL-993 |
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| Description | Purity ~97% (HPLC). A cell-permeable anthranilamide that acts as a potent VEGFR inhibitor (IC50=130, 23, and 18nM against VEGFR-1, -2, and -3, respectively; IC50=1.24nM against VEGF-induced human VEGFR-2 phosphorylation in CHO cells) by targeting the ATP-binding site of VEGFR in its inactive DFG-out conformation and effectively suppresses tumor growths (50 to 100mg/kg; p.o.) via its anti-angiogenesis activity in mice and rats in vivo, while inhibiting c-kit, CSF-1R/c-Fms, PDGFR-b, and c-Abl only at higher concentrations (IC50=236, 380, 640, and 2820nM, respectively). AAL933 and two other VEGFR inhibitors, KRN633 and SU5416, are also shown to inhibit hypoxia-induced HIF-1a expression (by <90% at 30uM) and transcription activation. Unlike KRN633 and SU5416, AAL933 prevents only hypoxia-induced Erk, but not Akt, phosphorylation in HeLa cells. Formula: C20H16F3N3O Molecular Weight: 371.4 Solubility: DMSO (100mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | VEGFR Tyrosine Kinase Inhibitor VI, AAL-993 (2-((4-Pyridyl)methyl)amino-N-(3-(trifluoromethyl)phenyl)benzamide, ZK260253, VEGFR2 Kinase Inhibitor XXXIII, VEGFR1 Kinase Inhibitor VIII, VEGFR3 Kinase Inhibitor VII, AAL993, PDGFR Tyrosine Kinase Inhibitor XXIII) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217866 |
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| Order / More Info | VEGFR Tyrosine Kinase Inhibitor VI, AAL-993 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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