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| Product Name | Forskolin, Coleus forskohlii |
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| Description | Purity ~99% (HPLC). The major cell-permeable diterpene isolated from the Indian plant Coleus forskohlii. At low doses, it acts as a positive inotropic agent. At higher doses, it serves as a hypotensive and vasodilatory agent due to its actions as a smooth muscle relaxant. No major side effects are observed at effective doses. Forskolins pharmacological activities are due to its activation of adenylate cyclase (EC50=4uM), resulting in increased cAMP levels. The exact mechanism of forskolins positive inotropic effect is unknown but may be related to a cAMP-dependent increase in Na+ permeability that results in indirect augmentation of Ca2+ release. Inhibits MAP kinase in rat renal mesangial cells (IC50= 25uM). Also acts as a Hh pathway antagonist. Shown to inhibit apoptosis in cerebellar granule cells and to induce apoptosis in resting human B lymphocytes. Formula: C22H34O7 Solubility: DMSO (5mg/ml) Molecular Weight: 410.5 |
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| Size | 10mg, 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Forskolin, Coleus forskohlii (7b-Acetoxy-8,13-epoxy-1α,6β,9α-trihydroxy-labd-14-en-11-one, Colforsin) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217370 |
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| Order / More Info | Forskolin, Coleus forskohlii from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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