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| Product Name | RBX1, Recombinant, Human, aa1-108, GST-Tag (E3 Ubiquitin-Protein Ligase RBX1) |
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| Description | Purity ~90% (SDS-PAGE). E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase (CRLs) complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. CRLs complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins, ARIH1 mediating addition of the first ubiquitin on CRLs targets. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubi |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Protein ZYP RING finger protein 75 RING-box protein 1 |
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| Gene, Accession, CAS # | SwissProt: P62877 |
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| Catalog # | 375011 |
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| Order / More Info | RBX1, Recombinant, Human, aa1-108, GST-Tag (E3 Ubiquitin-Protein Ligase RBX1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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