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| Product Name | NPTXR, Recombinant, Human, aa24-500, His-Tag (Neuronal Pentraxin Receptor, NPR) |
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| Description | Purity ~95% (SDS-PAGE). The Neuronal Pentraxin Receptor (NPTXR; also called NPR) is a 55-65kD, type II transmembrane glycoprotein within the Pentraxin family. NPTXR is co-expressed and forms heteromultimers with the related, secreted proteins NPTX1 and NPTX2/NARP. Human NPTXR is a 500 amino acid (aa) protein that includes a 477aa extracellular domain (ECD) with one calcium-binding Pentraxin domain. The human NPTXR ECD shares 88% and 89% aa sequence identity with mouse and rat NPTXR, respectively. A 62kD soluble form is generated by TACE/ADAM17 proteolytic cleavage C-terminal to the transmembrane segment. Soluble forms of 55kD and 45kD have also been reported. NPTXR is expressed on cerebellar Purkinje and granule cells, and hippocampal neurons of the CA1, CA3 and dentate gyrus regions. It is enriched on axonal membranes at excitatory synapses where, with NPTX1, it recruits the GluR4 subunit of AMPA-type glutamate receptors (AMPAR) to promote synaptogenesis. Synaptic activity stimulates |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: O95502 |
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| Catalog # | 145826 |
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| Order / More Info | NPTXR, Recombinant, Human, aa24-500, His-Tag (Neuronal Pentraxin Receptor, NPR) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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