| 产品详情 |
| Edit |   |
|---|
| Product Name | Histone Acetyl Transferase Inhibitor VII, CTK7A |
|---|
| Description | Purity ~99% (HPLC). A cell-permeable and water soluble hydrazinobenzoylcurcumin (HBC) compound that acts as a selective, reversible and mixed mode inhibitor of p300/CBP and PCAF histone acetyltransferases (IC50100uM). Blocks the autoacetylation of p300 and PCAF and histone acetylation, downregulates cyclin E expression and induces senescence-like growth arrest at 100uM in KB cells. Further, suppresses tumor growth in xenograft oral tumor nude mouse model (100mg/kg, i.p., b.i.d.) and reduces H3K14 and H3K9 acetylation levels. Reported to potently inhibit bFGF-induced bovine aortic endothelial cells (BAECs) invasion and tube formation with an IC50 of 0.93uM and binds to Ca2+/calmodulin with high-affinity (=8.11uM) and antagonize its functions in HCT15 cells. Formula: C28H23N2NaO6 Molecular Weight: 506.5 Solubility (100mg/ml): DMSO Method for Determining |
|---|
| Size | 10mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Histone Acetyl Transferase Inhibitor VII, CTK7A (HBC, Na 4-(3,5-bis-(2-(4-Hydroxy-3-methoxy-phenyl)-ethyl)-4,5-dihydro-pyrazol-1-yl)-benzoic Acid, Na Salt Hydroxy-methoxy-phenyl-ethyl-dihydro-pyrazolyl-benzoic acid, Na Salt Sodium-4-(3,5-bis(4-hydroxy-3-methoxystyryl)-1H-pyrazol-1-yl)benzoate, HAT Inhibitor VII, p300/CBP Inhibitor V, PCAF Inhibitor III, ) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 217427 |
|---|
| Price | |
|---|
| Order / More Info | Histone Acetyl Transferase Inhibitor VII, CTK7A from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|