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| Product Name | Histone Acetyltransferase Inhibitor VIII, NU9056 |
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| Description | Purity ~97% (HPLC). A cell-permeable disulfane compound that is reported to be more potent against KAT5/Tip60 than PCAF, p300, and GCN5 in cell-free HAT activity assays (IC50 ≤2, ≤36, ≤60, and >100uM, respectively) and effectively reduce H3K14, H4K8, H4K16, but not alpha-tubulin, acetylation level in LNCaP prostate cancer cells (max inhibition at 5-10uM). Shown to induce cell cycle arrest and apoptosis (17 to 24uM) in LNCaP cultures and exhibit antiproliferation activity in both androgen-responsive and androgen-independent CaP cultures (GI50 from 7.5 to 27uM). Solubility: DMSO Formula: C?H?N?S? Primary Target: KAT5 |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Histone Acetyltransferase Inhibitor VIII, NU9056 (1,2-Bis(isothiazol-5-yl)disulfane, 1,2-di(isothiazol-5-yl)disulfane, KAT5 Inhibitor I, Tip60 Inhibitor I, HAT Inhibitor VIII, p300/CBP Inhibitor VII, PCAF Inhibitor V) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217428 |
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| Order / More Info | Histone Acetyltransferase Inhibitor VIII, NU9056 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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