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| Product Name | Slit1, aa1-915, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). Slit1 is a member of the Slit family of large secreted axon guidance molecules that are ligands for Robo receptors (1, 2). Like other mammalian family members, the 1534aa, ~200kD human Slit1 contains a 33aa signal sequence followed by 23 leucine-rich repeats (LRR, aa34-900) and 9 EGF-like sequences (aa930-1454) (2). Mammalian Slits also contain a laminin-G domain between EGF6 and EGF7 (aa1166-1339), and a C-terminal cysteine-rich domain (cysteine knot; aa1459-1534) (2). Heparin sulfates are required for interaction of Robo with Slit LRR domains (2, 3). Within the LRR domains, human Slit1 shares 96% aa identity with mouse, rat, and bovine, 98% with equine and 91% with canine Slit1. Human Slits 1, 2 and 3 share 68-74% aa identity within the LRR domains. One potential isoform of 1641aa has 10aa inserted after aa338 within LRR9 and lacks aa793-816 within LRR20-21 (4). Two more potential isoforms of 1520 and 1461aa diverge at the C-terminus (aa1453 and 1411, respecti |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Slit1, aa1-915, Recombinant, Human (Slit Homolog 1, Slit Homolog 1 Protein, Slit-1, KIAA0813, Multiple Epidermal Growth Factor-like Domains 4, MEGF4, OTTHUMP00000059392, SLIL1, SLIT3, SLIT-3) |
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| Gene, Accession, CAS # | Accession: NP_003052 |
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| Catalog # | S1014-19A |
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| Price | |
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| Order / More Info | Slit1, aa1-915, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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