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| Product Name | WP-1130 |
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| Description | Purity >98% by TLC. Cell-permeable. WP1130 acts as a partly selective DUB (deubiquitinases) inhibitor, directly inhibiting DUB activity of USP9x, USP5, USP14, and UCH37, which are known to regulate survival protein stability and 26S proteasome function. WP1130-mediated inhibition of tumor-activated DUBs results in downregulation of antiapoptotic and upregulation of proapoptotic proteins, such as MCL-1 and p53. Blocks JAK2 signaling via JAK2 ubiquitination. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (S,E)-3-(6-Bromopyridin-2-yl)-2-cyano-N-(1-phenylbutyl)acrylamide, Degrasyn |
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| Gene, Accession, CAS # | CAS: 856243-80-6 |
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| Catalog # | LS-H2636 |
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| Price | |
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| Order / More Info | WP-1130 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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