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| Product Name | Recombinant Human Lysosomal acid lipase/cholesteryl ester hydrolase |
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| Description | 22-399; Mature full length protein. MW: 70.4kD. Purity >90% as determined by SDS-PAGE. Crucial for the intracellular hydrolysis of cholesteryl esters and triglycerides that have been internalized via receptor-mediated endocytosis of lipoprotein particles. Important in mediating the effect of LDL (low density lipoprotein) uptake on suppression of hydroxymethylglutaryl-CoA reductase and activation of endogenous cellular cholesteryl ester formation. |
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| Size | 0.01 mg (Yeast), 0.01 mg (E-Coli), 0.05 mg (Yeast), 0.05 mg (E-Coli), 0.1 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Cholesteryl esterase; Lipase A; Sterol esterase] |
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| Gene, Accession, CAS # | LIPA, Gene ID: 3988, Accession: NP_000226.2 |
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| Catalog # | MBS965818 |
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| Order / More Info | Recombinant Human Lysosomal acid lipase/cholesteryl ester hydrolase from MYBIOSOURCE INC. |
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| Product Specific References | Cloning and expression of cDNA encoding human lysosomal acid lipase/cholesteryl ester hydrolase. Similarities to gastric and lingual lipases.Anderson R.A., Sando G.N.J. Biol. Chem. 266:22479-22484(1991) Purification, characterization and molecular cloning of human hepatic lysosomal acid lipase.Ameis D., Merkel M., Eckerskorn C., Greten H.Eur. J. Biochem. 219:905-914(1994) Tissue and cellular specific expression of murine lysosomal acid lipase mRNA and protein.Du H., Witte D.P., Grabowski G.A.J. |
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