| 产品详情 |
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| Product Name | UNC0224 |
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| Description | Purity >98%. The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0224 is a potent and selective G9a HMTase inhibitor, exhibiting an IC50 value of 15 nM. Isothermal titration calorimetry revealed UNC0224 binds to G9a with a Kd value of 29 nM. UNC0224 also inhibits GLP, a closely-related H3K9 HMTase, with assay-dependent IC50 values of 20-58 nM, but is more than 1,000-fold selective against SET7/9 (a H3K4 HMTase) and SET8 (a H4K20 HMTase). |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 7-[3-(dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine |
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| Gene, Accession, CAS # | CAS: 1197196-48-7 |
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| Catalog # | LS-H10367 |
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| Price | |
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| Order / More Info | UNC0224 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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