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| Product Name | UNC2025 |
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| Description | Purity >98%. UNC2025 is a potent, orally bioavailable inhibitor of the tyrosine kinases Mer and Flt3 (IC50 s = 0.74 and 0.80 nM, respectively). It less potently inhibits Axl and Tyro3 (IC50 s = 14 and 17 nM, respectively) and a panel of related kinases. UNC2025 blocks colony formation of Mer- and Flt3-dependent tumor cell lines and inhibits Mer phosphorylation in bone marrow leukemia cells in vivo . Pharmacokinetic studies suggest that orally administered UNC2025 at 3 mg/kg will suffice to provide 90% inhibition of Mer and Flt3 at 30 min. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | trans -4-[2-(butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-cyclohexanol |
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| Gene, Accession, CAS # | CAS: 1429881-91-3 |
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| Catalog # | LS-H10377 |
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| Order / More Info | UNC2025 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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