| 产品详情 |
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| Product Name | UNC3230 |
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| Description | Purity >95%. Phosphatidylinositol-4-phosphate 5-kinase type-1 Gamma (PIP5K1C) is a lipid kinase that generates phosphatidylinositol-4,5-bisphosphate (PIP2 ) in nociceptive dorsal root ganglia (DRG). Pain sensitization is regulated by multiple signaling pathways that are initiated by phospholipase C-mediated hydrolysis of PIP2 . UNC3230 is a small molecule inhibitor of PIP5K1C (IC50 = 41 nM, Kd = 51 nM). It does not inhibit any other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 3-kinases. At 100 nM, UNC3230 decreases PIP2 membrane levels in cultured DRG neurons by 45% and significantly reduces calcium signaling. At 2 nM, it displays antinociceptive effects in mouse models of chronic pain when administered intrathecally or injected into inflamed hindpaw. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-[(cyclohexylcarbonyl)amino]-2-(phenylamino)-4-thiazolecarboxamide |
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| Gene, Accession, CAS # | CAS: 1031602-63-7 |
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| Catalog # | LS-H10379 |
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| Price | |
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| Order / More Info | UNC3230 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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