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| Product Name | NO-Losartan A |
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| Description | Angiotensin II is a hormone that plays an important role in regulating blood pressure.{9986} Elevated levels of angiotensin II are implicated in inducing and maintaining hypertension, and also in the development of atherosclerosis. Both of these effects are mediated by the angiotensin II type 1 (AT1) receptor.{12999} Losartan is a mammalian AT1 receptor antagonist with a Ki of 5-20 nM.{12997} In humans, losartan effectively controls hypertension while protecting renal function.{12996} NO causes vasodilation and also inhibits platelet and neutrophil aggregation in the endothelium.{6818,13090} NO-losartan A possesses similar anti-hypertensive effects to losartan, with the addition of the vasodilating effects of NO release.{12442} |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | AT1 receptors antagonists NO-donors nitric oxides angiotensins II type 1 hormones regulates blood pressure regulating hypertension atherosclerosis mammalian renal functions vasodilation vasodilating inhibits platelets neutrophils aggregation endothelium anti-hypertensives losartans |
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| Gene, Accession, CAS # | CAS: 791122-48-0 |
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| Catalog # | 10006456-1 |
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| Order / More Info | NO-Losartan A from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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