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| Product Name | Interferon-induced Helicase C Domain-containing Protein 1, Recombinant, Human, aa700-1025, His-SUMO-tag |
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| Description | Purity ~90% (SDS-PAGE). Interferon-induced Helicase C Domain-containing Protein 1, Recombinant, Human, aa700-1025, His-SUMO-tag (IFIH1). Innate immune receptor which acts as a Cytoplasmic domain sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Clinically amyopathic dermatomyositis autoantigen 140kD, Short name: CADM-140 autoantigen Helicase with 2 CARD domains, Short name: Helicard Interferon-induced with helicase C domain protein 1 Melanoma differentiation-associated protein 5 Short name: MDA-5 Murabutide down-regulated protein RIG-I-like receptor 2 Short name: RLR-2 RNA helicase-DEAD box protein 116 |
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| Gene, Accession, CAS # | SwissProt: Q9BYX4 |
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| Catalog # | 405959 |
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| Order / More Info | Interferon-induced Helicase C Domain-containing Protein 1, Recombinant, Human, aa700-1025, His-SUMO-tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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