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| Product Name | Corneodesmosin, Recombinant, Human (CDSN, D6S586E, HTSS, S protein) |
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| Description | Purity ≥95% (SDS-PAGE). Corneodesmosin, al so known as CDSN and the S gene product , is a highly polymorphic secreted glycoprotein that plays an important structural role in the skin. It is expressed by differentiated keratinocytes in the corneal layer of the skin and is a major component of corneodesmosomes. It is also expressed in the inner root sheath of hair follicles. Corneodesmosome has a high content of glycine, serine, and proline residues that promote its folding into a series of Gly-loop domains. Corneodesmosin forms oligomers and associates homophilically to strengthen the adhesion between corneocytes. Corneodesmosin-deficient mice exhibit a detachment of the corneal layer of the skin as well as hypotrichosis of the scalp and baldness. Corneodesmosin is secreted by keratinocytes as a 52-56kD molecule which is then subjected to repeated sequential N- and C-terminal proteolysis. Species of 46, 43, 36, and 15kD are present in corneocytes. Cleavage of the N-terminal Gly-loop dim |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: AAN70994 |
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| Catalog # | C7900-87 |
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| Order / More Info | Corneodesmosin, Recombinant, Human (CDSN, D6S586E, HTSS, S protein) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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