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| Product Name | CRISP-4, Recombinant, Mouse, 6-His-Tag (Cysteine-rich Secretory Protein 4, Crisp4) |
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| Description | Purity ~95% (SDS-PAGE). CRISP-4 is one of several CRISPs (cysteine-rich secretory proteins) that contain 16 invariant cysteine residues and show structural homolgy to snake, insect, and lizard venom proteins. These proteins consist of an N-terminal SCP/CAP domain, a hinge region, and a cysteine-rich CRISP domain. CRISPs are expressed in discrete but overlapping regions of the male reproductive tract and play a role in spermatozoa adhesion with Sertoli cells and oocytes, decapacitation, and the acrosomal reaction. CRISP-4 facilitates the progesterone-induced acrosomal reaction by inhibiting calcium conductance through the TRPM8 channel on sperm. Mouse CRISP-4 is secreted as a 32kD protein in the epididymis (primarily the caput region), vas deferens, and seminal vesicle. It is also associated with spermatozoa from the testis and caudal epididymis as a 26-28kD molecule. Its expression is induced at the onset of puberty in an androgen-dependent fashion. Mouse and rat CRISP-1 are additional |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Accession: NP_084309 |
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| Catalog # | C9018-59 |
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| Order / More Info | CRISP-4, Recombinant, Mouse, 6-His-Tag (Cysteine-rich Secretory Protein 4, Crisp4) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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