| 产品详情 |
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| Product Name | Foxo1 Inhibitor, AS1842856 |
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| Description | Purity ~98% (HPLC). A cell-permeable oxodihydroquinoline that preferentially inhibits the transcription activity of Forkhead box O family member Foxo1 (IC503nM) over that of the functionally related Foxo3a and Foxo4 (70%, 20%, and 3% inhibition, respectively, in HepG2-based reporter assays; [AS184256]0nM) via direct binding of the active Foxo1, but not the Ser256-phosphorylated/inactive form of Foxo1. Shown to inhibit gluconeogenesis in rat heptoma Fao cultures (IC50CnM against glucose production) in vitro and in liver of both non-diabetic and diabetic mice during a 26-hour fasting period (100mg/kg/8h p.o.) in vivo. Formula: C18H22FN3O3 Molecular Weight: 347.4 Solubility: DMSO (50mg/ml) |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Foxo1 Inhibitor, AS1842856 (5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic Acid) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217371 |
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| Order / More Info | Foxo1 Inhibitor, AS1842856 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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