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| Product Name | p300/CBP Inhibitor VI, L002 |
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| Description | Purity ~99% (HPLC). A cell-permeable phenylsulfonyloxyiminocyclohexadienone compound that acts as a potent, selective, and reversible inhibitor of p300 histone acetyl transferase (IC50 = 1.98uM). Shown to occupy Ac-CoA binding pocket of p300, and less potent to CBP, PCAF, GCN5 and GNAT. Suppresses Histone H3 and H4 acetylation in triple negative breast cancer cell line MDAMB-468 as well as in HCT116 cell line and blocks p300-mediated STAT3 phosphorylation in pancreatic cancer cell line MIA Paca-2. Does neither inhibit the activities of histone deacetylases 1, 6, and 11 nor 8-diverse histone methyltransferases tested (DOT1, EZH1, G9a, PRMT1, SETD2, SET7-9, SMYD2, and SUV39H2). Reported to suppress tumor growth in mice bearing tumor xenografts of MDAMB-468 cell line (at 500 µg/100 ul, i.p. twice a week). Solubility: DMSO Primary Target: p300 HAT |
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| Size | 10mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | p300/CBP Inhibitor VI, L002 (4-(4-Methoxyphenylsulfonyloxyimino)-2,6-dimethyl-2,5-cyclohexadien-1-one, GCN5 Inhibitor III, Histone Acetyltransferase Inhibitor IX, PCAF Inhibitor IV) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217616 |
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| Order / More Info | p300/CBP Inhibitor VI, L002 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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