| 产品详情 |
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| Product Name | MitoBloCK-6 |
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| Description | Purity ~98% (HPLC). A cell-permeable, stable dichlorosalicylaldehyde Schiff's base that acts as a potent, selective inhibitor of Mia40/Erv1 redox-mediated import pathway (IC50 = 700nM, 900nM, and 1.4uM for ALR, Erv1, and Erv2, respectively). Significantly reduces the import of CX9 proteins, Erv1, Tim23, and ADP/ATP carrier (AAC). However, it does not affect mitochondrial membrane integrity as evidenced by the lack of aconitase, AAC, Tim54, Mia40, and cytochrome c release. Has no effect on protein disulfide isomerase, flavin adenine dinucleotide, and succinate dehydrogenase activities and does not disrupt mitochondrial net work or reduce viability of cells even at high concentrations (~100uM in HeLa and HEK293 cells). Reported to specifically cause cytochrome c release, activate caspase-3, and induce apoptosis in human embryonic stem cells (~20uM), but not in differentiated cells. Reversibly impairs cardiac development and reduces heart rate in zebra fish that is attributed to mitochond |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | MitoBloCK-6 (2-(((4-Anilinophenyl)imino)methyl)-4,6-dichlorophenol, 2,4-Dichloro-6-(((((phenylamino)phenyl)imino)methyl)phenol), Mitochondrial Protein Import Blocker from the Carla Koehler Laboratory, MB6, MB-6) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217552 |
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| Order / More Info | MitoBloCK-6 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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