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| Product Name | DR4, Recombinant, Human (Soluble TRAIL Receptor-1, sTRAIL Receptor-1, TNFRSF10A, Apo2) |
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| Description | Purity ~98% (SDS-PAGE). TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic ``death domain,'' which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-1/DR4 is a protein (215aa residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain. Source: Recombinant protein corresponding to 215aa residues from human DR4, expressed in E. coli. Molecular Weight: ~22.7kD Biological Activity: Measured by its ability to inhibit apoptosis in LN-18 cells. The expected ED50 for this effect is 0.4-0.5ug/ml. Endotoxin: <0.1ng/ug of protein (<1EU/ug) AA Sequence: MSGTGAAAAT PSKVWGSSAG RIEPRGGGRG ALPTSMGQHG PSARARAGRA PGPRPAREAS PRLRVHKTFK FVVVGVLLQV VPSSAATIKL HDQSIGTQQW EHSPLGELCP PGSHRSERPG ACNRCTEGVG YTNASQQLFA CLPCTACKSD EEERSPCTTT RNTACQCKPG TFRNDNSAEM CRKCSTGCPR GMV |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | uble TRAIL Receptor-1, DR4, TNFRSF10A, Apo |
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| Gene, Accession, CAS # | TNFRSF10A, Gene ID: 8797, Accession: O00220 |
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| Catalog # | 219702 |
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| Order / More Info | DR4, Recombinant, Human (Soluble TRAIL Receptor-1, sTRAIL Receptor-1, TNFRSF10A, Apo2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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