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| Product Name | DR5, soluble Recombinant, Human |
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| Description | Purity ≥ 98% by SDS-PAGE and HPLC analyses. Endotoxin: ≤ 0.1ng/ug (1EU/ug). Human sTRAIL Receptor-2, also known as DR5 (Death Receptor-5), is a member of the TNF receptor family. Human sTRAIL Receptor-2 is a 14.9kD protein containing 133 amino acid residues comprising the extracellular domain of TRAIL Receptor-2. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family. DR4 was recently identified as the receptor for TRAIL. A novel death domain containing receptor for TRAIL was more recently identified and designated DR5, Apo2, TRAIL-R2, TRICK2, or KILLER by several groups independently (1-7). Like DR4, DR5 transcript is widely expressed in normal tissues and in many types of tumor cells. DR5 binds to TRAIL and mediates TRAIL induced cell death. Overexpression of DR5 induces apoptosis and activates NF-kB. Biological Activity: Determined by its inhibitory effect |
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| Size | 10ug, 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | DR5, soluble Recombinant, Human (Apo2, Trail-R2, TRAIL Receptor2, Trick2, Killer, Death Receptor5, CD262, KILLER, KILLER/DR5, TNFRSF10B, TRANCE-R, TRICKB, Tumor Necrosis Factor Receptor Superfamily, Member 10b, ZTNFR9) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | D9300-51 |
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| Order / More Info | DR5, soluble Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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