| 产品详情 |
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| Product Name | Oleoyl 3-carbacyclic Phosphatidic Acid |
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| Description | Purity >95%. Cyclic phosphatidic acids (cPAs) are naturally occurring analogs of lysophosphatidic acid (LPA) in which the sn -2 hydroxy group forms a 5-membered ring with the sn -3 phosphate. Carba-derivatives of cPA (ccPA) are modified at the sn -2 (2-ccPA) or sn -3 (3-ccPA) linkage, preventing the opening of cPA to produce lysophosphatidic acid (LPA). Oleoyl 3-Carbacyclic Phosphatidic Acid (3-ccPA 18:1) is a cyclic LPA analog that contains the 18:1 fatty acid, oleate, at the sn -1 position of the glycerol backbone. At 25 µM, it inhibits the transcellular migration of MM1 cells across mesothelial cell monolayers in response to fetal bovine serum (90.1%) or LPA (99.9%) without affecting proliferation. 3-ccPA 18:1, at 0.1-1.0 µM, significantly inhibits autotaxin, an enzyme that is important in cancer cell survival, growth, migration, invasion, and metastasis. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (9Z)-9-octadecenoic acid, (2-hydroxy-2-oxido-1,2-oxaphospholan-5-yl)methyl ester, 3-ccPA 18:1 |
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| Gene, Accession, CAS # | CAS: 779333-58-3 |
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| Catalog # | LS-H9162 |
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| Order / More Info | Oleoyl 3-carbacyclic Phosphatidic Acid from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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