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| Product Name | CLEC9A, Recombinant, Human (C-type Lectin Domain Family 9 Member A, UNQ9341/PRO34046) |
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| Description | Purity ~95% (SDS-PAGE, reducing conditions). CLEC9a (C-type lectin domain family 9 member A), also known as DNGR-1, is a type II transmembrane glycoprotein member of the C-type lectin superfamily. Mature human CLEC9a consists of a 35aa cytoplasmic domain with an ITAM-like motif, a 21aa transmembrane segment, and a 185aa extracellular domain (ECD) that contains a stalk region and one C-type lectin domain (CTLD). Within the ECD, human CLEC9a shares 57% aa sequence identity with mouse and rat CLEC9a. Although the CTLD of CLEC9a structurally resembles that of other C-type lectins, it lacks the conserved residues that typically mediate calcium and carbohydrate binding. CLEC9a is expressed as a disulfide-linked homodimer of approximately 50kD N-glycosylated subunits. Human CLEC9a expression is restricted to a subpopulation of BDCA-3+ conventional dendritic cells (cDC) and CD16-monocytes. BDCA-3+ cDC are analagous to mouse CD8+ cDC which are specialized in antigenic cross-presentation in comp |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q6UXN8 |
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| Catalog # | C5839-73K |
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| Order / More Info | CLEC9A, Recombinant, Human (C-type Lectin Domain Family 9 Member A, UNQ9341/PRO34046) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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