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| Product Name | Recombinant Human Clusterin |
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| Description | 23-224aa; Partial. MW: 27.9kD. Purity >90% as determined by SDS-PAGE. Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. |
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| Size | 0.05 mg, 0.2 mg, 0.5 mg, 1 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [Aging-associated gene 4 protein; Apolipoprotein J; Apo-J; Complement cytolysis inhibitor; CLI; Complement-associated protein SP-40,40; Ku70-binding protein 1; NA1/NA2; Testosterone-repressed prostate message 2; TRPM-2] |
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| Gene, Accession, CAS # | CLU, Gene ID: 1191, Accession: NP_001822.3 |
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| Catalog # | MBS1265506 |
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| Order / More Info | Recombinant Human Clusterin from MYBIOSOURCE INC. |
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| Product Specific References | Molecular structure and functional characterization of a human complement cytolysis inhibitor found in blood and seminal plasmaidentity to sulfated glycoprotein 2, a constituent of rat testis fluid.Jenne D.E., Tschopp J.Proc. Natl. Acad. Sci. U.S.A. 86:7123-7127(1989) Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration.Wong P., Taillefer D., Lakins J., Pineault J., Chader G., Tenniswood M.Eur. J. Biochem. 221:917-925(1994 |
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