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| Product Name | PUMA Fragment, Recombinant, Human, aa76-170, His-Tag |
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| Description | Purity ~95%. Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse. PUMA is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. This PUMA recombinant protein is recognized by several ProSci PUMA monoclonal antibodies, but not the two polyclonal antibodies. Source: Recombinant protein corresponding to human PUMA fragment, fused to His-tag and strepII-tag at N-terminal expressed |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PUMA Fragment, Recombinant, Human, aa76-170, His-Tag (Bcl-2-binding Component 3, JFY-1, p53 Up-regulated Modulator of Apoptosis, BBC3) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 149767 |
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| Order / More Info | PUMA Fragment, Recombinant, Human, aa76-170, His-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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