| 产品详情 |
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| Product Name | IRAK M, Blocking Peptide (IL-1 Receptor-associated Kinase) |
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| Description | Purified 60-70%. Peptide (CSSKFSWDEYEQYKKE) corresponding to amino acids 581 to 596 of human IRAK-M (3). Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-kB by IL-1/Toll receptors (1,2), which is a pivotal transcription factor mediating in?ammatory and immune response. A novel member in the IRAK/Pelle family was recently identi?ed and designated IRAK-M(3). IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-kB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated in?ammatory responses to cytokine IL-1 and LPS. Applications: Suitable for use in ELISA and Western Blot. |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | I8600-20P |
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| Order / More Info | IRAK M, Blocking Peptide (IL-1 Receptor-associated Kinase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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