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| Product Name | IRAK4, Recombinant, Human, GST-Tag |
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| Description | Purity ≥95%. (IRAKs) are important mediators in the signal transduction of the Toll/IL-1 receptor (TIR) family. Members of the TIL family play a role in innate immune responses by coordinating host defense mechanisms. IRAK4 is the most recently discovered IRAK protein. IRAK-4 has been shown to interact with IRAK-1 and TRAF6 in an IL-1-dependent manner, and overexpression of IRAK-4 has been shown to activate NFkB as well as mitogen-activated protein (MAP) kinase pathways. Studies demonstrate that mice lacking IRAK4 are severely impaired in their IL-1, Toll-like receptor (TLR) signaling and response to viral and bacterial challenges; this indicates that IRAK4 has an important role in innate immunity. Humans lacking IRAK 4 exhibit pyogenic bacterial infections, while their blood and fibroblast cells fail to activate NF-kB. IRAK-4 is believed to be required for the LPS-induced activation of antigenpresenting cells. Source: Recombinant human IRAK4, aa2-end, with N-terminal GST tag, expresse |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | IRAK4, Recombinant, Human, GST-Tag (IRAK4, REN64, NY-REN-64, Interleukin-1 receptor-associated kinase 4, IRAK-4 mutated form 1, Interleukin-1 receptor associated kinase 4) |
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| Gene, Accession, CAS # | Accession: NM_001114182 |
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| Catalog # | I8600-17H |
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| Order / More Info | IRAK4, Recombinant, Human, GST-Tag from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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