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| Product Name | RAF265 |
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| Description | Purity >98%. RAF265 is a dual inhibitor of mutant B-RafV600E and vascular endothelial growth factor receptor 2 (EC50 s = 0.14 and 0.19 µM, respectively, in cell-based assays). It can also inhibit wild-type B-Raf, platelet-derived growth factor receptor, colony-stimulating factor 1R, RET, c-KIT, SRC, and STE20 with IC50 values ranging from 20-100 nM. RAF265 can inhibit proliferation of melanoma and colorectal cancer cell lines with active BRAF mutations as well as suppress tumor growth in melanoma xenograft models bearing B-RafV600E mutations. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]-1H-benzimidazol-2-amine, CHIR265 |
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| Gene, Accession, CAS # | CAS: 927880-90-8 |
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| Catalog # | LS-H9654 |
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| Order / More Info | RAF265 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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