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| Product Name | JW 74 |
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| Description | Inhibitor of canonical Wnt signaling (IC50 = 790 nM). Targets the β-catenin destruction complex (GSK-3?/AXIN/APC). Increases AXIN2 and decreases active β-catenin levels in colorectal cancer (CRC) cells. Also arrests cell cycle in G1 and inhibits proliferation of CRC cells in vitro. Inhibits tumor growth and formation in mouse models. Purity 99%. MW (observed): 456.52 |
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| Size | 10 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine |
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| Gene, Accession, CAS # | CAS: 863405-60-1 |
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| Catalog # | 5653/10 |
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| Price | |
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| Order / More Info | JW 74 from TOCRIS BIOSCIENCE
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| Product Specific References | PubMed: 29736258 |
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| 产品资料 |
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