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| Product Name | SIRT6 Inhibitor, Fluorometric, Screening BioAssay™ Kit |
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| Description | SIRT6 or Sirtuin 6 proteins are a class of proteins that possess either histone deacetylase or mono-ribosyltransferase activity. SIRT6 is a nuclear sirtuin that has been associated with aging, cellular protection, sugar metabolism and certain types of cancer. Broad therapeutic applications are foreseen for SIRT6 inhibitors, including uses in diabetes, immune-mediated disorders, and cancer. Unlike other known protein deacetylases, which simply hydrolyze acetyl-lysine residues, the sirtuin-mediated deacetylation reaction hydrolyzes acetyl-lysine and NAD. This hydrolysis yields the deacetylated substrate, O-acetyl-ADP-ribose and nicotinamide, itself an inhibitor of sirtuin activity. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. Intended Use: For screening, characterizing, and studying SIRT6 inhibitors Test Principle: In this Sirtuin 6 inhibitor screening BioAssay™ Kit, Sirtuin 6 deacetylates the substra |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 301286 |
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| Order / More Info | SIRT6 Inhibitor, Fluorometric, Screening BioAssay™ Kit from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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