| 产品详情 |
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| Product Name | Adenosine A3 Receptor Antagonist, MRS 1523 |
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| Description | Purity ~95% (HPLC). A pyridine derivative that acts as a highly selective antagonist of A3 receptor with excellent potency in both humans and rodents (Ki = 18.9nM for human A3R, and 113nM for rat A3R). Exhibits only a trivial antagonistic activity towards A1 and A2A receptors (Ki = 15.6uM and 2.05uM for rat A1R and A2AR, respectively). Abolishes the agonistic effects of Cl-IB-MECA on A3R-mediated proliferation of primary human coronary smooth muscle cells. Also, reported to block NECA-induced bronchoconstriction in an allergic murine model. Formula: C23H29NO3S Solubility: DMSO Primary Target: A3 Receptor Primary Target Ki: 18.9nM Molar Mass: 399.55 |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Adenosine A3 Receptor Antagonist, MRS 1523 (3-propyl-6-ethyl-5[(ethylthio)carbonyl]-2-phenyl-4-propyl-3-pyridine-carboxylate, MRS 1523, MRS-1523) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217156 |
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| Order / More Info | Adenosine A3 Receptor Antagonist, MRS 1523 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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