| 产品详情 |
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| Product Name | JIB-04 |
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| Description | Purity >98% by NMR, TLC. JIB-04 is a novel specific inhibitor of the Jumonji family of histone demethylases in vitro, in cancer cells and in tumors in vivo. IC50 = 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively. Reduces tumor burden and prolongs life in a mouse model. Suppresses translation initiation and enhances mTOR inhibitor sensitivity. Inhibits the growth of temozolomide-resistant glioblastoma cells and crosses the blood brain barrier. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (E)-5-Chloro-2-(2-(phenyl(pyridine-2-yl)methylene)hydrazinyl)pyridine |
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| Gene, Accession, CAS # | CAS: 199596-05-9 |
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| Catalog # | LS-H14721 |
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| Order / More Info | JIB-04 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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