| 产品详情 |
| Edit |   |
|---|
| Product Name | JIB-04 |
|---|
| Description | Purity >95%. JIB-04 is a pyridine hydrazone that broadly inhibits Jumonji histone demethylases (IC50 s values = 230, 340, 435, 445, 855 and 1,100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3, and JMJD2C, respectively). It does not inhibit histone deacetylases and has minimal effect on the iron-containing enzymes methylcytosine dioxygenase TET1 and hypoxia-inducible factor prolyl hydroxylase 2. JIB-04 inhibits Jumonji demethylase activity, alters gene expression, and blocks viability of cancer cells but not in patient-matched normal cells. It also inhibits Jumonji demethylase activity in cancer cells in vivo, resulting in reduced tumor burden and prolonged survival. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | phenyl-2-pyridinyl-methanone, (E,E)-2-(5-chloro-2-pyridinyl)hydrazone, JHDM Inhibitor VII, NSC 693627 |
|---|
| Gene, Accession, CAS # | CAS: 199596-05-9 |
|---|
| Catalog # | LS-H8287 |
|---|
| Price | |
|---|
| Order / More Info | JIB-04 from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|