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| Product Name | 10-Nitrooleate |
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| Description | Purity >98%. Nitrated unsaturated fatty acids, such as 10- and 12-nitrolinoleate (LNO2 ), cholesteryl nitrolinoleate, and nitrohydroxylinoleate, represent a new class of endogenous lipid-derived signalling molecules. LNO2 isomers serve as potent endogenous ligands for PPARGamma and can also decompose or be metabolized to release nitric oxide. 10-Nitrooleate is one of two regioisomers of nitrooleate, the other being 9-nitrooleate (OA-NO2 ; used for the mixture of isomers), which are formed by nitration of oleic acid in approximately equal proportions in vivo . Peroxynitrite, acidified nitrite, and myeloperoxidase in the presence of H2 O2 and nitrite, all mediate the nitration of oleic acid. OA-NO2 is found in human plasma as the free acid and esterified in phospholipids at concentrations of 619 ± 52 nM and 302 ± 369 nM, respectively. OA-NO2 activates PPARGamma approximately 7-fold at a concentration of 1 µM and effectively promotes differentiation 3T3-L1 preadipocytes to adipocytes at 3 µM. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 10-nitro-9E-octadecenoic acid, 10-nitro-9-trans-Octadecenoic Acid, 10-Nitrooleic Acid |
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| Gene, Accession, CAS # | CAS: 875685-46-4 |
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| Catalog # | LS-H5769 |
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| Order / More Info | 10-Nitrooleate from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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