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| Product Name | Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) (AA 220-479) protein (His tag) |
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| Description | Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in most tissues. CASP10 cleavage by Granzyme B and autocatalytic activity generate the two active subunits: Caspase-10 subunit p23/17, Caspase-10 subunit p12. Caspases are a family of cytosolic aspartate-specific cysteine proteases involved in the execution-phase of cell apoptosis, the initiation and execution. Human caspases can be subdivided into three functional groups: cytokine activation (caspase-1, -4, -5, and -13), apoptosis initiation (caspase-2, -8, -9, -and -10), and apoptosis execution (caspase-3, -6, and -7). CASP10 cleaves and activates caspases 3 and 7, but itself is processed by caspase 8. Defects in CASP10 are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome.Alternative Names: Caspase-10, CASP-10, Apoptotic Protease Mch-4, FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2, FLICE2, ICE-Like Apoptotic Protease 4, CASP10, MCH4 |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | xCaspase-10|alps2|caspace-10|caspase-10|flice2|mch4|xCaspace-10|ALPS2|FLICE2|MCH4 |
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| Gene, Accession, CAS # | Gene ID: 843 |
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| Catalog # | ABIN1692216 |
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| Order / More Info | Caspase 10, Apoptosis-Related Cysteine Peptidase (CASP10) (AA 220-479) protein (His tag) from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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