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| Product Name | Endoplasmic Reticulum Associated Amyloid Beta Binding Protein, Human, Control Peptide (ERAB) |
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| Description | Highly purified. Control Peptide for E2291-52A (antiserum) and E2291-53A (affinity purified antibody). An intracellular protein termed ERAB (262aa, Endoplasmic reticulum associated Ab binding protein on chromosome X) has been cloned and linked with Ab neurotoxicity. ERAB has structural homology with short-chain alcohol dehydrogenases (hydroxysteroid dehydrogenases and acetyl-CoA reductases). Interestingly, ERAB localizes to endoplasmic reticulum despite the absence of a classical transmembrane sequence. However, in the presence of Ab, ERAB-Ab complex translates to the inner plasma membrane. Alzheimer patients have strong ERAB activity. Normal brains have virtually no ERAB. In addition, Ab neurotoxicity can be reduced by blocking ERAB and increased by its overexpression. Applications: Suitable for use in ELISA and Antibody Blocking. Not suitable for use in Western Blot due to low molecular weight. |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | E2291-54A |
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| Order / More Info | Endoplasmic Reticulum Associated Amyloid Beta Binding Protein, Human, Control Peptide (ERAB) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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