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| Product Name | Endostatin, Recombinant, Human (COL18A1) |
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| Description | Purity ~95% (SDS-PAGE). Endostatin, an endogenous non-glycosylated inhibitor of endothelial cell proliferation and angiogenesis, is an ~181aa, 20kD proteolytic fragment of the C-terminal non-collagenous domain of type XVIII collagen (1, 2). It is produced and/or trimmed by metalloproteinases such as MMP-2 and MMP-9, and cathepsins S, B and L (3, 4). The N-terminal ~27aa of Endostatin appear to contain the majority of its activity (4, 5). This region contains three zinc binding sites that are thought to be critical for its anti-endothelial and anti-tumor effects, as well as multiple cleavage sites that, when used, can modify its activity (4, 5). Human Endostatin shares 84-87%aa sequence identity with mouse, rat, bovine and equine Endostatin. Endostatin inhibits endothelial cell growth by inducing cell cycle arrest in G1 phase and initiating apoptosis (1, 2). It is also thought to down-regulate angiogenesis by blocking VEGF-induced endothelial cell migration (6, 7). It alters the effect |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 167646 |
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| Order / More Info | Endostatin, Recombinant, Human (COL18A1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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