| 产品详情 |
| Edit |   |
|---|
| Product Name | Endostatin, Recombinant, Mouse, aa1591-1774 (COL18A1) |
|---|
| Description | Purity ~95% (SDS-PAGE). Endostatin, an endogenous nonglycosylated inhibitor of endothelial cell proliferation and angiogenesis, is an ~181 amino acid (aa), 20kD proteolytic fragment of the Cterminal noncollagenous domain of type XVIII collagen (1, 2). It is produced and/or trimmed by metalloproteinases such as MMP2 and MMP9, and cathepsins S, B and L (3, 4). The Nterminal ~27aa of Endostatin appear to contain the majority of its activity (4, 5). This region contains zinc binding sites that are thought to be critical for its antiendothelial and antitumor effects, as well as multiple cleavage sites that, when used, can modify its activity (4, 5). Mouse Endostatin shares 96% aa sequence identity with rat and 8587% with human, bovine and equine Endostatin. Endostatin inhibits endothelial cell growth by inducing cell cycle arrest in G1 phase and initiating apoptosis (1, 2). It is also thought to downregulate angiogenesis by blocking VEGFinduced endothelial cell migration (6, 7). |
|---|
| Size | 50ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | SwissProt: P39061 |
|---|
| Catalog # | 145788 |
|---|
| Price | |
|---|
| Order / More Info | Endostatin, Recombinant, Mouse, aa1591-1774 (COL18A1) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|