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| Product Name | [Pyruvate Dehydrogenase [lipoamide]] Kinase Isozyme 4, Mitochondrial, Recombinant Mouse, aa138-368, His-tag (Pdk4) |
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| Description | Purity ~85% (SDS-PAGE). Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Pyruvate dehydrogenase kinase isoform 4 |
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| Gene, Accession, CAS # | SwissProt: O70571 |
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| Catalog # | 406031 |
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| Order / More Info | [Pyruvate Dehydrogenase [lipoamide]] Kinase Isozyme 4, Mitochondrial, Recombinant Mouse, aa138-368, His-tag (Pdk4) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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