| 产品详情 |
| Edit |   |
|---|
| Product Name | Pyruvate Kinase Activator |
|---|
| Description | Purity ~98% (HPLC). A cell-permeable and biologically stable (t1/2 = 277.2 and 117.5 min., respectively, in human and mouse liver microsome preparation) tetrahydroquinoline-sulfonamide that enhances the donor PEP, but not the acceptor ADP, substrate affinity toward pyruvate kinase isoform PKM2 (Km = 0.4 vs. 1.9 mM with or without 10uM activator) and acts as a potent PKM2-selective activator (AC50 = 90nM using rhPKM2; ACmax = 88%), displaying much reduced activity toward PKL (<25% at 57uM) and no effect toward PKM1 or PKR. Formula: C15H11ClF2N2O3S Molecular Weight: 372.8 Solubility: DMSO (100mg/ml, clear, colorless solution) |
|---|
| Size | 25mg |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Pyruvate Kinase Activator (N-(4-Chloro-3-fluorophenyl)-7-fluoro-2-oxo-1,2,3,4-tetrahydroquinoline-6-sulfonamide, PKM2 Activator I) |
|---|
| Gene, Accession, CAS # | n/a |
|---|
| Catalog # | 217723 |
|---|
| Price | |
|---|
| Order / More Info | Pyruvate Kinase Activator from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|