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| Product Name | CD226, Fc Chimera, Recombinant, Mouse (DNAM1, DNAX Accessory Molecule-1) |
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| Description | Purity ≥ 80%, as determined by SDS-PAGE and visualized by silver stain. Endotoxin ≤ 1EU. DNAX accessory molecule-1 (DNAM-1), also known as CD226, is a 65kD type I transmembrane glycoprotein that belongs to the immunoglobulin superfamily (1). Mature mouse DNAM has a 236 amino acid (aa) extracellular domain (ECD) that contains two Ig-like C2-set domains, and possesses a 58 aa cytoplasmic region that contains motifs for binding PDZ domains and band 4.1 family proteins (1, 2). Within the ECD, mouse DNAM-1 shares 52% and 86% aa sequence identity with human and rat DNAM-1, respectively. Additional cDNA transcripts of mouse DNAM-1 may give rise to secreted or transmembrane isoforms with ECD deletions. DNAM-1 is expressed on several lymphoid and myeloid cell types and interacts with CD155/PVR and Nectin-2/CD112 (2-4). Ligation of DNAM-1 promotes the activation of NK cells, CD8+ T cells, and mast cells (3-7), induces dendritic cell maturation, initiates megakaryocyte and activated platelet adhe |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q8K4F0 |
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| Catalog # | M4699-02 |
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| Order / More Info | CD226, Fc Chimera, Recombinant, Mouse (DNAM1, DNAX Accessory Molecule-1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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