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| Product Name | CD137, Fc Chimera, Recombinant, Rat, aa24-188 (4-1BB, TNFRSF9, ILA) |
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| Description | Purity ~95% (SDS-PAGE). 4-1BB, also known as CD137 and TNFRSF9, is an ~30kD transmembrane glycoprotein in the TNF receptor superfamily. 4-1BB functions in the development and activation of multiple immune cells (1). Mature rat consists of a 166 amino acid (aa) extracellular domain (ECD) with four TNFR cysteine-rich repeats, a 21aa transmembrane segment, and a 48aa cytoplasmic domain. Within the ECD, rat 4-1BB shares 60% and 79% aa sequence identity with human and mouse 4-1BB, respectively. 4-1BB is expressed as a disulfidelinked homodimer on various populations of activated T cells including CD4+, CD8+, memory CD8+, NKT, and regulatory T cells (2-5) as well as on myeloid and mast cell progenitors, dendritic cells, mast cells, and bacterially infected osteoblasts (6-9). It binds with high affinity to the transmembrane 4-1BB Ligand/TNFSF9 which is expressed on antigen presenting cells and myeloid progenitor cells (6, 10). This interaction co-stimulates the proliferation, activation, and |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 145778 |
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| Order / More Info | CD137, Fc Chimera, Recombinant, Rat, aa24-188 (4-1BB, TNFRSF9, ILA) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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