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| Product Name | FR122047 (hydrate) |
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| Description | FR122047 is a selective inhibitor of COX-1. The IC50 values for inhibition of human COX-1 and COX-2 are 0.028 and 65 µM, respectively.{11222} In human platelet-rich plasma, FR122047 inhibits arachidonic acid, collagen, and ADP-induced platelet aggregation with an IC50 of 180-200 nM, which is nearly 100 times more potent than aspirin.{10791} Unlike aspirin, FR122047 does not induce gastric damage upon oral administration at doses (100 mg/kg) far in excess of the dose needed for complete suppression of platelet COX-1. In some models of inflammation, such as collagen-induced arthritis in the rat, FR122047 has an anti-inflammatory effect, implying a role for COX-1 in these models.{10672} |
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| Size | 5 mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 130717-51-0 FR-122047 cyclooxygenases COX-1 inhibitors hydrates hydrochlorides COX1 PGHS1 PGHS-1 prostaglandin synthases inhibition inhibits selective selectivity platelet aggregation antiinflammatory atherosclerosis |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 10039-5 |
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| Order / More Info | FR122047 (hydrate) from CAYMAN CHEMICAL COMPANY |
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| Product Specific References | n/a |
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