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| Product Name | CD40,Fc, Recombinant, Human |
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| Description | Purity >95% (SDS-PAGE). CD40 belongs to the TNF-receptor superfamily and is essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development and germinal center formation. The interaction of CD40-CD40L is necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. CD40 is constitutively expressed by antigen presenting cells, including dendritic cells, B cells and macrophages. Consistent with its widespread expression on normal cells, CD40 is also expressed on a wide range of tumor cells, including non-Hodgkin's and Hodgkin's lymphomas, myeloma and some carcinomas including nasopharynx, bladder, cervix, kidney and ovary. Biological Activity: Blocks the binding of CD40L to CD40. Sequence: The Fc portion of human IgG1 is fused to the C-terminus of human CD40 (aa 21-193). |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CD40,Fc, Recombinant, Human (Tumor Necrosis Factor Receptor Superfamily Member 5, TNFRSF5, CD40L Receptor) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 44658 |
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| Price | |
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| Order / More Info | CD40,Fc, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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