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| Product Name | a2-Macroglobulin, Human Plasma, Fast Form |
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| Description | Purity ~95% (SDS-PAGE). Alpha 2 Macroglobulin (A2M) is a plasma protease inhibitor which has been shown to exist in two forms. The Slow Form of A2M (S-A2M) is the form which possesses the ability to bind and inhibit proteases by a ``trap'' method. The Fast Form of A2M (F-A2M) is generated when S-A2M undergoes a conformational change due to either entrapment of a protease in the A2M bait region, or chemical cleavage of an internal thiol ester bond located near the bait region. F-A2M does not possess the ability to bind and inhibit protease activity. F-A2M is rapidly taken up by the liver, with a half-life of 2-4 minutes. In vivo, F-A2M typically represents only 0.17-0.7% of the total A2M in blood plasma of adults. The F-A2M plasma concentration is, however, increased in many disease states including pancreatitis, multiple sclerosis and sepsis. F-A2M has also been implicated in the inhibition of amyloid formation associated with Alzheimer's disease and spongiform encephalopathy. Source: Hu |
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| Size | 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | a2-Macroglobulin, Human Plasma, Fast Form (C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5, A2M, CPAMD5, FWP007) |
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| Gene, Accession, CAS # | A2M, Gene ID: 2, SwissProt: P01023 |
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| Catalog # | M1150-01P |
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| Order / More Info | a2-Macroglobulin, Human Plasma, Fast Form from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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