| 产品详情 |
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| Product Name | Tin Protoporphyrin IX (chloride) |
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| Description | Heme oxygenase (HO) converts protoheme to biliverdin, which in turn is enzymatically metabolized to bilirubin . While HO-2 is constitutively expressed, HO-1 can be induced by its heme substrate as well as by heavy metals, oxidizing agents, and other environmental stresses. Tin protoporphyrin IX (SnPPIX) is a synthetic heme analog that selectively inhibits HO-1 (Ki = 11 nM) over HO-2 (IC50 = 7.5 µM). It also weakly inhibits endothelial nitric oxide synthase and soluble guanylyl cyclase (IC50 s = 35 and 30 nM, respectively). SnPPIX prevents hyperbilirubinemia in neonates by blocking HO-1 activity that increases postnatally. It is rapidly cleared from plasma and persists in certain tissues, including kidney, liver, and spleen. SnPPIX is commonly used as a tool to study the role of HO-1 activity in cells and in animals. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | (OC-6-13)-dichloro[7,12-diethenyl-3,8,13,17-tetramethyl-21H,23H-porphine-2,18-dipropanoato(4-)-?N21 ,?N22 ,?N23 ,?N24 ]-stannate(2-), dihydrogen, NSC 267099, SnPPIX |
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| Gene, Accession, CAS # | CAS: 14325-05-4 |
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| Catalog # | LS-H10226 |
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| Order / More Info | Tin Protoporphyrin IX (chloride) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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